![]() The prickle cell and basal layers are collectively referred to as the Malpighian layer. The basal, prickle cell and granular layers are metabolically active regions of the epidermis. The basal layer undergoes continuous mitosis throughout life. The daughter cells ascend the epidermal layers, while undergoing morphological changes throughout its journey. It also develops clefts and ridges that are perceived on the thickened areas of skin as imprints (i.e. The epidermis is significantly thicker in the regions of the palms and soles, when compared to other areas of the body. Furthermore, there are no sebaceous glands or hair follicles located in the skin in the palms and soles, while those structures are found in other areas of the body. The thick, hairless skin in the palms and soles are therefore called glabrous skin, while skin elsewhere is referred to as hirsute (hairy) skin. ![]() Stratum corneum - dead, non-nucleated cells filled with keratine filaments Stratum lucidum - present only in palms and soles translucent cells filled with keratine filaments Stratum granulosum - flattened, polygonal pycnotic cells that contain keratohyaline granules, Odland bodies Stratum spinosum - contains post-mitotic cells from stratum basale that contain keratine fibrils melanosomes, Langerhans cells Stratum basale (germinativum) - stem cells constantly undergoing mitosis, regenerate other layers Langerhans cells - antigen presenting cells Melanocytes - synthesise melanin that gives color to the skin and protects it from ultraviolet radiation Keratinocytes - squamous epithelial cells that originate from basal stem cells continuously mature from basal to corneum layer and desquamate Of note, the stratum lucidum is absent from hirsute skin but present in glabrous skin. The epidermis is made up a variety of cell types. Cell that contain keratin are known as keratinocytes. These are stratified squamous epithelial cells that are shed from the surface of the skin daily. Translucent cells containing keratin skin# Translucent cells containing keratin skin#.
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